/* Paleta de colores (hereda variables de home-page.css si existen; fallback seguros) */
:root {
    --color-bg-start: var(--hp-bg-start, #f5f7fa);
    --color-bg-end: var(--hp-bg-end, #c3cfe2);
    --color-primary: var(--hp-primary, #3498db);
    --color-primary-600: var(--hp-primary-600, #2980b9);
    --color-primary-dark: var(--hp-primary-dark, #1f618d);
    --color-accent: var(--hp-accent, #667eea);
    --color-text: var(--hp-text, #2c3e50);
    --color-muted: var(--hp-muted, #7f8c8d);
    --color-surface: var(--hp-surface, #ffffff);
    --color-success: var(--hp-success, #28a745);
    --color-warning: var(--hp-warning, #15e6d8);
    --color-danger: var(--hp-danger, #e74c3c);
    --color-card-shadow: rgba(0,0,0,0.08);
}

.dipole-grid-container {
    max-width: 100%;
}

.dipole-visualization-card {
    border: 1px solid rgba(0,0,0,0.06);
    border-radius: 8px;
    box-shadow: 0 2px 4px var(--color-card-shadow);
    transition: box-shadow 0.3s ease;
}

.dipole-visualization-card:hover {
    box-shadow: 0 4px 8px rgba(0,0,0,0.15);
}

.dipole-viewer {
    background: var(--color-surface);
    border-radius: 4px;
    position: relative;
    overflow: hidden;
}

.loading-placeholder {
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    text-align: center;
}

.dipole-info-compact {
    background: linear-gradient(135deg, var(--color-surface) 0%, #f3f6fb 100%);
    padding: 10px;
    border-radius: 4px;
    font-size: 0.9em;
}

.dipole-info-compact code {
    background: #e9ecef;
    padding: 2px 4px;
    border-radius: 3px;
}

/* ===== RESET Y BASE ===== */
* {
    margin: 0;
    padding: 0;
    box-sizing: border-box;
}

/* ===== LAYOUT PRINCIPAL ===== */
.family-analysis-body {
    font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif;
    background: linear-gradient(135deg, var(--color-bg-start) 0%, var(--color-bg-end) 100%);
    min-height: 100vh;
    color: var(--color-text);
    line-height: 1.6;
}

.family-container {
    max-width: 100%; /* ✅ Cambio: usar todo el ancho */
    margin: 0 auto;
    padding: 20px;
}

/* ===== HEADER ===== */
.family-header {
    margin-bottom: 30px;
    background: white;
    border-radius: 12px;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
    overflow: hidden;
}

.header-content {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: 25px 30px;
    background: linear-gradient(135deg, var(--color-accent) 0%, var(--color-primary) 100%);
    color: white;
}

.page-title {
    font-size: 2rem;
    font-weight: 700;
    display: flex;
    align-items: center;
    gap: 15px;
}

/* ===== BOTONES ===== */
.btn {
    padding: 12px 24px;
    border: none;
    border-radius: 8px;
    font-weight: 600;
    text-decoration: none;
    display: inline-flex;
    align-items: center;
    gap: 8px;
    cursor: pointer;
    transition: all 0.3s ease;
    font-size: 0.95em;
}

.btn-back {
    background: rgba(255,255,255,0.2);
    color: white;
    border: 2px solid rgba(255,255,255,0.3);
}

.btn-back:hover {
    background: rgba(255,255,255,0.3);
    transform: translateY(-2px);
}

.btn-primary {
    background: linear-gradient(135deg, var(--color-primary) 0%, var(--color-primary-600) 100%);
    color: white;
}

.btn-primary:hover {
    background: linear-gradient(135deg, var(--color-primary-600) 0%, var(--color-primary-dark) 100%);
    transform: translateY(-2px);
    box-shadow: 0 4px 12px rgba(0,0,0,0.12);
}

.btn-primary:disabled {
    background: #bdc3c7;
    cursor: not-allowed;
    transform: none;
    box-shadow: none;
}

.btn-secondary {
    background: linear-gradient(135deg, #95a5a6 0%, #7f8c8d 100%);
    color: white;
}

.btn-secondary:hover {
    background: linear-gradient(135deg, #7f8c8d 0%, #34495e 100%);
    transform: translateY(-2px);
}

.btn-visualize {
    width: 100%;
}

.btn-export {
    min-width: 150px;
}

/* ===== CARDS ===== */
.selection-card,
.visualization-card,
.stat-card {
    background: white;
    border-radius: 12px;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
    overflow: hidden;
    margin-bottom: 25px;
    border: 1px solid rgba(0,0,0,0.08);
    transition: all 0.3s ease;
}

.selection-card:hover,
.visualization-card:hover {
    box-shadow: 0 8px 25px rgba(0,0,0,0.12);
    transform: translateY(-2px);
}

.card-body {
    padding: 28px;
}

.card-header {
    background: linear-gradient(135deg, #f8f9fa 0%, #e9ecef 100%);
    padding: 20px 28px;
    border-bottom: 1px solid #dee2e6;
    display: flex;
    justify-content: space-between;
    align-items: center;
}

.card-header .section-title,
.card-header .card-title {
    margin: 0;
    color: #2c3e50;
    font-size: 1.2rem;
    font-weight: 700;
}

/* ===== SECCIONES ESPECÍFICAS ===== */
.family-selection-section {
    margin-bottom: 30px;
}

/* ✅ NUEVA ESTRUCTURA: Separación clara de secciones */
.selection-section {
    margin-bottom: 25px;
}

.control-group {
    display: flex;
    flex-direction: column;
    gap: 10px;
}

.control-label {
    font-weight: 600;
    color: #34495e;
    font-size: 1rem;
    letter-spacing: 0.3px;
}

.family-selector {
    padding: 14px 16px;
    border: 2px solid #ddd;
    border-radius: 8px;
    font-size: 1rem;
    background: white;
    color: #2c3e50;
    transition: all 0.3s ease;
    box-shadow: 0 2px 4px rgba(0,0,0,0.05);
}

.family-selector:hover {
    border-color: #3498db;
    box-shadow: 0 4px 8px rgba(52, 152, 219, 0.1);
}

.family-selector:focus {
    outline: none;
    border-color: #3498db;
    box-shadow: 0 0 0 4px rgba(52,152,219,0.15);
}

/* ✅ NUEVA SECCIÓN DE ACCIÓN: Botón centrado y destacado */
.action-section {
    display: flex;
    justify-content: center;
    align-items: center;
    margin: 30px 0;
    min-height: 80px;
    background: linear-gradient(135deg, rgba(52,152,219,0.05) 0%, rgba(102,126,234,0.05) 100%);
    border-radius: 12px;
    border: 2px dashed rgba(52,152,219,0.2);
    transition: all 0.3s ease;
}

.action-section:has(.btn:not(:disabled)):hover {
    background: linear-gradient(135deg, rgba(52,152,219,0.1) 0%, rgba(102,126,234,0.1) 100%);
    border-color: rgba(52,152,219,0.4);
}

/* ✅ BOTÓN GRANDE Y DESTACADO */
.btn-lg {
    padding: 16px 40px;
    font-size: 1.05em;
    border-radius: 10px;
    box-shadow: 0 4px 12px rgba(52,152,219,0.25);
    transition: all 0.3s ease;
    max-width: 100%;
    width: auto;
}

.btn-lg .btn-text {
    display: flex;
    align-items: center;
    gap: 8px;
}

.btn-lg i {
    font-size: 1.1em;
}

.btn-lg:hover:not(:disabled) {
    transform: translateY(-4px);
    box-shadow: 0 8px 20px rgba(52,152,219,0.35);
}

.btn-lg:active:not(:disabled) {
    transform: translateY(-2px);
}

.btn-lg:disabled {
    opacity: 0.6;
    cursor: not-allowed;
}

/* ===== ALERTAS E INFO ===== */
.family-info-alert {
    background: linear-gradient(135deg, #d4edda 0%, #c3e6cb 100%);
    border: 2px solid #28a745;
    border-radius: 12px;
    padding: 16px 20px;
    margin-top: 20px;
    margin-bottom: 20px;
    display: flex;
    align-items: center;
    gap: 12px;
    color: #155724;
    font-weight: 500;
    font-size: 0.95rem;
    box-shadow: 0 2px 8px rgba(40, 167, 69, 0.15);
    animation: slideInDown 0.4s ease-out;
}

.family-info-alert i {
    font-size: 1.2em;
    flex-shrink: 0;
}

/* ✅ Píldora de ayuda alineada a la derecha */
.family-hint {
    margin-left: auto;
    background: #e8f1fe;
    color: #1f3b66;
    border: 1px solid #c9ddff;
    padding: 6px 10px;
    border-radius: 999px;
    font-size: 0.85rem;
    display: inline-flex;
    align-items: center;
    gap: 6px;
}

.family-hint::before {
    content: '\f05a'; /* fa-info-circle */
    font-family: 'Font Awesome 6 Free';
    font-weight: 900;
    font-size: 0.9em;
    color: #3b82f6;
}

@keyframes slideInDown {
    from {
        opacity: 0;
        transform: translateY(-10px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

/* ===== LISTA DE PÉPTIDOS ===== */
.peptide-list-container {
    margin-top: 25px;
}

.peptide-card {
    background: white;
    border: 1px solid #dee2e6;
    border-radius: 8px;
    margin-top: 20px;
    overflow: hidden;
}

.peptide-card-header {
    background: linear-gradient(135deg, #f8f9fa 0%, #e9ecef 100%);
    padding: 15px 20px;
    border-bottom: 1px solid #dee2e6;
}

.peptide-card-title {
    font-size: 1.1rem;
    font-weight: 600;
    color: #2c3e50;
    display: flex;
    align-items: center;
    gap: 10px;
    margin: 0;
}

.peptide-card-body {
    padding: 20px;
}

/* ===== TABLAS ===== */
.peptide-table {
    width: 100%;
    border-collapse: collapse;
    margin-top: 15px;
    background: white;
    border-radius: 8px;
    overflow: hidden;
    box-shadow: 0 2px 8px rgba(0,0,0,0.1);
}

.peptide-table th {
    background: linear-gradient(135deg, #34495e 0%, #2c3e50 100%);
    color: white;
    padding: 15px 12px;
    text-align: left;
    font-weight: 600;
    font-size: 0.95rem;
}

.peptide-table td {
    padding: 12px;
    border-bottom: 1px solid #eee;
    vertical-align: top;
}

.peptide-table tr:hover {
    background: #f8f9fa;
}

.peptide-table tr:last-child td {
    border-bottom: none;
}

/* ✅ Columna de resaltado mejorada */
.highlight-cell {
    text-align: center;
    min-width: 150px;
}

.highlight-toggle-control {
    position: relative;
    display: inline-flex;
    align-items: center;
    gap: 8px;
    font-weight: 600;
    cursor: pointer;
    color: #1f3b66;
    user-select: none;
}

.highlight-toggle-input {
    position: absolute;
    opacity: 0;
    pointer-events: none;
    width: 1px;
    height: 1px;
    inset: 0;
}

.highlight-toggle-chip {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    padding: 6px 14px;
    border-radius: 999px;
    border: 1px solid rgba(31, 59, 102, 0.2);
    background: #f4f6fb;
    color: #1f3b66;
    font-size: 0.85rem;
    font-weight: 600;
    transition: all 0.25s ease;
    box-shadow: 0 2px 6px rgba(26, 54, 93, 0.08);
}

.highlight-toggle-chip i {
    font-size: 0.85rem;
}

.highlight-toggle-control.is-active .highlight-toggle-chip {
    background: linear-gradient(135deg, var(--color-primary) 0%, var(--color-primary-600) 100%);
    color: #fff;
    border-color: transparent;
    box-shadow: 0 6px 18px rgba(52, 152, 219, 0.35);
}

.highlight-toggle-control.is-active .highlight-toggle-chip i {
    color: inherit;
}

.highlight-toggle-input:focus-visible + .highlight-toggle-chip,
.highlight-toggle-chip:focus-visible {
    outline: 3px solid rgba(52, 152, 219, 0.35);
    outline-offset: 2px;
}

/* ===== SECUENCIAS ===== */
.sequence-container {
    max-width: 400px;
}

.sequence-text {
    font-family: 'Courier New', monospace;
    font-size: 0.85em;
    line-height: 1.3;
    word-break: break-all;
    background: #f8f9fa;
    padding: 6px 8px;
    border-radius: 4px;
    border: 1px solid #dee2e6;
    transition: all 0.3s ease;
    cursor: pointer;
    display: block;
}

.sequence-text:hover {
    background: #e7f3ff;
    border-color: #3498db;
}

.sequence-text[data-expanded="true"] {
    background: #e7f3ff;
    border-color: #3498db;
    color: #2c3e50;
}

/* ✅ Resaltado por modificación (posiciones 1-based) */
.sequence-text-readonly .seq-change,
.sequence-text .seq-change {
    display: inline-block;
    border: 2px solid var(--color-primary);
    border-radius: 4px;
    padding: 0 2px;
    margin: 1px 1px;
    background: color-mix(in srgb, var(--color-primary) 12%, transparent);
    box-shadow: 0 1px 0 rgba(0,0,0,0.08);
}

.sequence-text-readonly .seq-change:hover,
.sequence-text .seq-change:hover {
    border-color: var(--color-primary-600);
    background: color-mix(in srgb, var(--color-primary) 18%, transparent);
}

/* ===== BADGES Y ELEMENTOS PEQUEÑOS ===== */
.peptide-code {
    font-family: 'Courier New', monospace;
    font-weight: 700;
    color: #3498db;
    font-size: 0.95em;
}

.ic50-value {
    font-size: 0.9em;
    color: #7f8c8d;
}

.difference-badge {
    background: linear-gradient(135deg, #3589f8 0%, #3589f8 100%);
    color: white;
    padding: 4px 8px;
    border-radius: 4px;
    font-size: 0.75em;
    font-family: monospace;
    font-weight: 600;
}

/* ===== ÁREA DE VISUALIZACIÓN ===== */
.visualization-section {
    margin-bottom: 35px;
    animation: fadeInUp 0.5s ease-out;
}

.dipole-visualization-area {
    min-height: 0; /* Evitar rectángulo gigante */
    position: relative;
    background: transparent; /* Sin fondo para no crear bloque vacío */
    border-radius: 8px;
    margin-bottom: 12px;
}

.loading-state {
    text-align: center;
    padding: 80px 20px;
    display: flex;
    flex-direction: column;
    align-items: center;
    justify-content: center;
}

.spinner {
    width: 50px;
    height: 50px;
    border: 4px solid #f3f3f3;
    border-top: 4px solid var(--color-primary);
    border-radius: 50%;
    animation: spin 1s linear infinite;
    margin-bottom: 20px;
}

@keyframes spin {
    0% { transform: rotate(0deg); }
    100% { transform: rotate(360deg); }
}

@keyframes fadeInUp {
    from {
        opacity: 0;
        transform: translateY(20px);
    }
    to {
        opacity: 1;
        transform: translateY(0);
    }
}

.loading-text {
    color: #7f8c8d;
    font-size: 1.05rem;
    margin: 0;
}

/* ✅ Leyenda compacta sobre los visualizadores */
.dipole-legend {
    display: inline-flex;
    align-items: center;
    gap: 14px;
    padding: 8px 12px;
    background: white;
    border: 1px solid #e5e7eb;
    border-radius: 10px;
    box-shadow: 0 2px 6px rgba(0,0,0,0.06);
}

.dipole-legend .legend-item {
    display: inline-flex;
    align-items: center;
    gap: 6px;
    color: #374151;
    font-size: 0.9rem;
    white-space: nowrap;
}

.dipole-legend .legend-swatch {
    width: 14px;
    height: 14px;
    border-radius: 3px;
    background: var(--legend-color, #999);
    box-shadow: inset 0 0 0 1px rgba(0,0,0,0.1);
}

/* ===== GRID DE VISUALIZACIONES ===== */
.visualization-grid {
    display: grid;
    grid-template-columns: repeat(3, 1fr); /* ✅ 3 COLUMNAS para mejor distribución */
    gap: 20px;
    margin-top: 25px;
    width: 100%;
}

.visualization-actions {
    margin-top: 18px;
    margin-bottom: 8px;
    padding: 16px 20px;
    background: #f7f9ff;
    border: 1px solid rgba(31, 59, 102, 0.1);
    border-radius: 12px;
    display: flex;
    justify-content: space-between;
    align-items: center;
    gap: 16px;
}

.visualization-actions__hint {
    margin: 0;
    color: #4b5a75;
    font-size: 0.92rem;
}

.visualization-actions__buttons {
    display: flex;
    gap: 12px;
    flex-wrap: wrap;
}

/* Botón toggle de filtro con estilo consistente */
.btn-toggle-filter {
    position: relative;
}

.btn-toggle-filter[aria-pressed="true"] {
    background: linear-gradient(135deg, var(--color-primary-600, #2980b9) 0%, var(--color-primary-dark, #1f618d) 100%);
    box-shadow: 0 6px 20px rgba(52, 152, 219, 0.5);
}

.btn-toggle-filter[aria-pressed="true"] #toggleFilterIcon::before {
    content: "\f00d"; /* fa-times icon */
}

.btn-badge {
    min-width: 24px;
    height: 24px;
    border-radius: 999px;
    background: rgba(255, 255, 255, 0.3);
    color: white;
    font-size: 0.75rem;
    display: inline-flex;
    align-items: center;
    justify-content: center;
    font-weight: 700;
    margin-left: 4px;
    border: 2px solid rgba(255, 255, 255, 0.5);
    box-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
}

.dipole-visualization-card.is-hidden {
    display: none;
}

.dipole-visualization-card {
    background: white;
    border: 2px solid #dee2e6;
    border-radius: 12px;
    overflow: hidden;
    transition: all 0.3s ease;
    box-shadow: 0 4px 12px rgba(0,0,0,0.1);
    min-height: 500px; /* ✅ Ajustado para 3 columnas */
    display: flex;
    flex-direction: column;
}

.dipole-visualization-card:hover {
    transform: translateY(-4px);
    box-shadow: 0 8px 25px rgba(0,0,0,0.15);
    border-color: #3498db;
}

/* ✅ Resaltado de tarjeta seleccionada desde la tabla (checkbox "Resaltar") */
.dipole-visualization-card.highlighted-card {
    border-color: var(--color-accent) !important; /* matches design palette */
    box-shadow: 0 0 0 3px color-mix(in srgb, var(--color-accent) 35%, transparent), 0 10px 24px rgba(0,0,0,0.18);
    position: relative;
    transform: translateY(-2px);
}

.dipole-visualization-card.highlighted-card::after {
    content: 'Resaltado';
    position: absolute;
    top: 10px;
    right: 10px;
    background: var(--color-accent);
    color: #fff;
    font-size: 11px;
    font-weight: 700;
    letter-spacing: 0.3px;
    padding: 4px 8px;
    border-radius: 999px;
    box-shadow: 0 2px 6px rgba(0,0,0,0.15);
    pointer-events: none;
}

.dipole-card-header {
    background: linear-gradient(135deg, var(--color-primary) 0%, var(--color-primary-600) 100%);
    color: white;
    padding: 14px 15px;
    flex-shrink: 0;
}

.dipole-card-title {
    font-size: 0.95rem;
    font-weight: 700;
    margin: 0 0 3px 0;
    display: flex;
    align-items: center;
    gap: 8px;
}

.dipole-card-subtitle {
    font-size: 0.8rem;
    opacity: 0.9;
    margin: 0;
}

.dipole-viewer {
    height: 320px; /* ✅ Optimizado para 3x3 */
    background: #f8f9fa;
    position: relative;
    overflow: hidden;
    flex-grow: 1;
}

.dipole-info-compact {
    background: linear-gradient(135deg, #f8f9fa 0%, #e9ecef 100%);
    padding: 12px 15px;
    border-top: 1px solid #dee2e6;
    flex-shrink: 0;
}

.dipole-stats {
    display: grid;
    grid-template-columns: 1fr 1fr 1fr;
    gap: 8px;
    margin-bottom: 8px;
}

.dipole-stat {
    text-align: center;
}

.stat-label {
    font-size: 0.7rem;
    color: #7f8c8d;
    margin-bottom: 2px;
    font-weight: 600;
}

.stat-value {
    font-size: 0.9rem;
    font-weight: 700;
    color: #2c3e50;
}

.dipole-vector-info {
    text-align: center;
    margin-top: 6px;
}

.vector-code {
    font-family: 'Courier New', monospace;
    font-size: 0.7rem;
    background: white;
    padding: 6px 8px; /* ✅ Reducido */
    border-radius: 4px;
    border: 1px solid #dee2e6;
    color: #2c3e50;
    line-height: 1.2;
}

/* ===== ANÁLISIS DE ÁNGULOS ===== */
.angle-analysis-section {
    margin-top: 30px;
}

.angle-analysis-card {
    background: white;
    border-radius: 12px;
    box-shadow: 0 4px 20px rgba(0,0,0,0.12);
    overflow: hidden;
    transition: all 0.3s ease;
}

.angle-analysis-card .card-header {
    background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
    color: white;
    padding: 25px 30px;
    border-bottom: none;
    display: flex;
    justify-content: space-between;
    align-items: center;
    flex-wrap: wrap;
    gap: 20px;
}

.angle-analysis-card .header-left {
    flex: 1;
    min-width: 300px;
}

.angle-analysis-card .header-right {
    display: flex;
    align-items: center;
}

.angle-analysis-card .section-title {
    color: white;
    font-size: 1.4rem;
    font-weight: 700;
    margin: 0 0 8px 0;
    display: flex;
    align-items: center;
    gap: 12px;
}

.angle-analysis-card .section-subtitle {
    color: rgba(255, 255, 255, 0.9);
    font-size: 0.95rem;
    margin: 0;
    font-weight: 400;
}

.angle-charts-grid {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 30px;
    padding: 30px;
}

.angle-chart-container {
    background: linear-gradient(135deg, #f8f9fa 0%, #e9ecef 100%);
    border-radius: 12px;
    padding: 20px;
    border: 2px solid #dee2e6;
    transition: all 0.3s ease;
}

.angle-chart-container:hover {
    border-color: #667eea;
    transform: translateY(-4px);
    box-shadow: 0 8px 25px rgba(102, 126, 234, 0.2);
}

.angle-chart-container .chart-title {
    color: #2c3e50;
    font-size: 1.1rem;
    font-weight: 600;
    margin: 0 0 15px 0;
    text-align: center;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 8px;
}

.angle-chart {
    min-height: 350px;
    background: white;
    border-radius: 8px;
    padding: 10px;
}

/* ===== CONTROLES ROSE PLOT ===== */
.rose-plot-controls {
    display: flex;
    align-items: center;
    gap: 15px;
}

.rose-plot-controls .control-label {
    color: white;
    font-size: 0.9rem;
    font-weight: 600;
    display: flex;
    align-items: center;
    gap: 8px;
    margin: 0;
}

.toggle-switch-container {
    display: flex;
    align-items: center;
    gap: 12px;
    background: rgba(255, 255, 255, 0.15);
    padding: 10px 16px;
    border-radius: 999px;
    backdrop-filter: blur(10px);
}

.toggle-switch-container .toggle-label {
    color: white;
    font-size: 0.9rem;
    font-weight: 600;
    white-space: nowrap;
}

.toggle-switch {
    position: relative;
    display: inline-block;
    width: 50px;
    height: 26px;
}

.toggle-switch input {
    position: absolute;
    opacity: 0;
    width: 100%;
    height: 100%;
    margin: 0;
    cursor: pointer;
    z-index: 2;
}

.toggle-slider {
    position: absolute;
    cursor: pointer;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background-color: rgba(255, 255, 255, 0.3);
    transition: 0.3s;
    border-radius: 26px;
}

.toggle-slider:before {
    position: absolute;
    content: "";
    height: 20px;
    width: 20px;
    left: 3px;
    bottom: 3px;
    background-color: white;
    transition: 0.3s;
    border-radius: 50%;
    box-shadow: 0 2px 4px rgba(0,0,0,0.2);
}

.toggle-switch input:checked + .toggle-slider {
    background-color: rgba(76, 175, 80, 0.8);
}

.toggle-switch input:checked + .toggle-slider:before {
    transform: translateX(24px);
}

.toggle-switch input:focus + .toggle-slider {
    box-shadow: 0 0 0 3px rgba(255, 255, 255, 0.3);
}

/* ===== ANÁLISIS DE ZONAS FUNCIONALES ===== */
.zones-analysis-section {
    margin-top: 30px;
}

.zones-analysis-card {
    background: white;
    border-radius: 12px;
    box-shadow: 0 4px 20px rgba(0,0,0,0.12);
    overflow: hidden;
    transition: all 0.3s ease;
}

.zones-analysis-card .card-header {
    background: linear-gradient(135deg, #f093fb 0%, #f5576c 100%);
    color: white;
    padding: 25px 30px;
    border-bottom: none;
    display: flex;
    justify-content: space-between;
    align-items: center;
    flex-wrap: wrap;
    gap: 20px;
}

.zones-analysis-card .header-left {
    flex: 1;
    min-width: 300px;
}

.zones-analysis-card .header-right {
    display: flex;
    align-items: center;
}

.zones-analysis-card .section-title {
    color: white;
    font-size: 1.4rem;
    font-weight: 700;
    margin: 0 0 8px 0;
    display: flex;
    align-items: center;
    gap: 12px;
}

.zones-analysis-card .section-subtitle {
    color: rgba(255, 255, 255, 0.95);
    font-size: 0.95rem;
    margin: 0;
    font-weight: 400;
}

/* Toggle de modo */
.zones-mode-toggle {
    display: flex;
    align-items: center;
    gap: 12px;
    background: rgba(255, 255, 255, 0.15);
    padding: 10px 16px;
    border-radius: 999px;
    backdrop-filter: blur(10px);
}

.zones-mode-toggle .toggle-label {
    color: white;
    font-size: 0.9rem;
    font-weight: 600;
    white-space: nowrap;
}

/* Switch toggle */
.switch {
    position: relative;
    display: inline-block;
    width: 50px;
    height: 26px;
}

.switch input {
    opacity: 0;
    width: 0;
    height: 0;
}

.slider {
    position: absolute;
    cursor: pointer;
    top: 0;
    left: 0;
    right: 0;
    bottom: 0;
    background-color: rgba(255, 255, 255, 0.3);
    transition: 0.3s;
    border-radius: 26px;
}

.slider:before {
    position: absolute;
    content: "";
    height: 20px;
    width: 20px;
    left: 3px;
    bottom: 3px;
    background-color: white;
    transition: 0.3s;
    border-radius: 50%;
    box-shadow: 0 2px 4px rgba(0,0,0,0.2);
}

input:checked + .slider {
    background-color: rgba(255, 255, 255, 0.5);
}

input:checked + .slider:before {
    transform: translateX(24px);
}

/* Banner informativo */
.zones-info-banner {
    background: linear-gradient(135deg, #e3f2fd 0%, #bbdefb 100%);
    border-left: 4px solid #2196f3;
    padding: 15px 20px;
    margin: 20px 30px;
    border-radius: 8px;
    display: flex;
    gap: 15px;
    align-items: flex-start;
}

.zones-info-banner i {
    color: #2196f3;
    font-size: 1.2rem;
    margin-top: 2px;
}

.zones-info-banner .banner-content {
    flex: 1;
    font-size: 0.9rem;
    color: #1565c0;
    line-height: 1.6;
}

.zones-info-banner strong {
    color: #0d47a1;
    margin-right: 5px;
}

/* Leyenda de zonas */
.zones-legend {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 20px;
    margin: 20px 30px;
    padding: 20px;
    background: #f8f9fa;
    border-radius: 12px;
    border: 2px solid #dee2e6;
}

.legend-family-info {
    grid-column: 1 / -1;
    text-align: center;
    font-size: 1rem;
    font-weight: 700;
    color: #f5576c;
    padding: 10px;
    background: white;
    border-radius: 8px;
    margin-bottom: 10px;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 10px;
}

.legend-section {
    background: white;
    border-radius: 8px;
    padding: 15px;
    border: 1px solid #e0e0e0;
}

.legend-axis-title {
    color: #2c3e50;
    font-size: 0.95rem;
    font-weight: 700;
    margin: 0 0 12px 0;
    padding-bottom: 8px;
    border-bottom: 2px solid #e0e0e0;
    display: flex;
    align-items: center;
    gap: 8px;
}

.legend-items {
    display: flex;
    flex-direction: column;
    gap: 8px;
}

.legend-item {
    display: flex;
    align-items: center;
    gap: 10px;
    padding: 5px 0;
}

.legend-item-muted {
    opacity: 0.6;
    font-style: italic;
}

.legend-color {
    width: 18px;
    height: 18px;
    border-radius: 4px;
    box-shadow: 0 2px 4px rgba(0,0,0,0.15);
    flex-shrink: 0;
}

.legend-text {
    font-size: 0.85rem;
    font-weight: 500;
    color: #2c3e50;
    line-height: 1.3;
}

/* Grid de gráficos de zonas */
.zones-charts-grid {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 30px;
    padding: 30px;
}

.zone-chart-container {
    background: linear-gradient(135deg, #f8f9fa 0%, #e9ecef 100%);
    border-radius: 12px;
    padding: 20px;
    border: 2px solid #dee2e6;
    transition: all 0.3s ease;
}

.zone-chart-container:hover {
    border-color: #f5576c;
    transform: translateY(-4px);
    box-shadow: 0 8px 25px rgba(245, 87, 108, 0.2);
}

.zone-chart-container .chart-title {
    color: #2c3e50;
    font-size: 1.1rem;
    font-weight: 600;
    margin: 0 0 15px 0;
    text-align: center;
    display: flex;
    align-items: center;
    justify-content: center;
    gap: 8px;
}

.zone-chart {
    min-height: 350px;
    background: white;
    border-radius: 8px;
    padding: 10px;
}

/* ===== ESTADÍSTICAS OPTIMIZADAS ===== */
.statistics-grid {
    display: grid;
    grid-template-columns: repeat(2, 1fr);
    gap: 25px;
    margin-top: 30px;
    width: 100%;
}

.stat-card {
    background: white;
    border-radius: 12px;
    box-shadow: 0 4px 15px rgba(0,0,0,0.1);
    overflow: hidden;
    transition: all 0.3s ease;
}

.stat-card:hover {
    transform: translateY(-4px);
    box-shadow: 0 8px 25px rgba(0,0,0,0.15);
}

.stat-card .card-header {
    background: linear-gradient(135deg, #3498db 0%, #2980b9 100%);
    color: white;
    padding: 18px 20px;
    border-bottom: none;
}

.stat-card .card-header .card-title {
    color: white;
    font-size: 1.15rem;
    margin: 0;
}

.stats-content {
    padding: 20px;
}

.stats-grid {
    display: grid;
    grid-template-columns: repeat(3, 1fr);
    gap: 15px;
    text-align: center;
}

.stats-item {
    padding: 16px;
    background: linear-gradient(135deg, #f8f9fa 0%, #e9ecef 100%);
    border-radius: 10px;
    border: 2px solid #dee2e6;
    transition: all 0.3s ease;
}

.stats-item:hover {
    background: linear-gradient(135deg, #e9ecef 0%, #dfe3e8 100%);
    border-color: #3498db;
    transform: translateY(-2px);
    box-shadow: 0 4px 12px rgba(52,152,219,0.15);
}

.stats-label {
    font-size: 0.85rem;
    color: #7f8c8d;
    margin-bottom: 8px;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.5px;
}

.stats-value {
    font-size: 1.4rem;
    font-weight: 700;
    color: #2c3e50;
}

/* ===== RESPONSIVE DESIGN ACTUALIZADO ===== */
@media (max-width: 1400px) {
    .family-container {
        padding: 15px;
    }
    
    .dipole-viewer {
        height: 340px;
    }
}

@media (max-width: 1200px) {
    .visualization-grid {
        grid-template-columns: repeat(3, 1fr); /* ✅ Mantener 3 columnas en tablets grandes */
        gap: 18px;
    }
    
    .dipole-visualization-card {
        min-height: 480px;
    }
    
    .dipole-viewer {
        height: 300px;
    }
    
    .statistics-grid {
        grid-template-columns: 1fr; /* Stack en una columna */
        gap: 20px;
    }
    
    .angle-charts-grid {
        grid-template-columns: repeat(3, 1fr);
        gap: 20px;
        padding: 20px;
    }
    
    .angle-analysis-card .card-header {
        flex-direction: column;
        align-items: flex-start;
        gap: 15px;
    }
    
    .rose-plot-controls {
        width: 100%;
        flex-direction: column;
        align-items: flex-start;
        gap: 10px;
    }
    
    .zones-charts-grid {
        grid-template-columns: repeat(3, 1fr);
        gap: 20px;
        padding: 20px;
    }
    
    .zones-analysis-card .card-header {
        flex-direction: column;
        align-items: flex-start;
        gap: 15px;
    }
    
    .zones-mode-toggle {
        padding: 8px 12px;
        gap: 10px;
    }
}

@media (max-width: 992px) {
    .visualization-grid {
        grid-template-columns: repeat(2, 1fr); /* ✅ 2 columnas en tablets */
        gap: 20px;
    }
    
    .dipole-visualization-card {
        min-height: 460px;
    }
    
    .dipole-viewer {
        height: 320px;
    }
    
    .statistics-grid {
        grid-template-columns: 1fr;
    }
    
    .angle-charts-grid {
        grid-template-columns: repeat(2, 1fr);
        gap: 20px;
    }
    
    .zones-charts-grid {
        grid-template-columns: repeat(2, 1fr);
        gap: 20px;
    }
    
    .zones-analysis-card .card-header {
        flex-direction: column;
        align-items: flex-start;
    }
    
    .zones-analysis-card .header-right {
        width: 100%;
        justify-content: center;
    }
}

@media (max-width: 900px) {
    .visualization-grid {
        grid-template-columns: repeat(2, 1fr);
        gap: 18px;
    }
    
    .dipole-viewer {
        height: 300px;
    }
    
    .statistics-grid {
        grid-template-columns: 1fr;
    }
    
    .angle-charts-grid {
        grid-template-columns: 1fr;
        gap: 15px;
        padding: 15px;
    }
    
    .zones-charts-grid {
        grid-template-columns: 1fr;
        gap: 15px;
        padding: 15px;
    }
    
    .zones-legend {
        flex-direction: column;
        gap: 10px;
        align-items: flex-start;
    }
}

@media (max-width: 768px) {
    .family-container {
        padding: 10px;
    }
    
    .zones-legend {
        grid-template-columns: 1fr;
        gap: 12px;
        padding: 15px;
        margin: 15px;
    }
    
    .legend-section {
        padding: 12px;
    }
    
    .header-content {
        flex-direction: column;
        gap: 15px;
        text-align: center;
        padding: 15px;
    }
    
    .page-title {
        font-size: 1.4rem;
    }
    
    .selection-section {
        margin-bottom: 20px;
    }
    
    .action-section {
        min-height: 70px;
        margin: 20px 0;
        padding: 15px;
    }
    
    .btn-lg {
        padding: 14px 28px;
        font-size: 1em;
    }
    
    .card-header {
        flex-direction: column;
        gap: 10px;
        text-align: center;
        padding: 12px 15px;
    }
    
    .section-title,
    .card-title {
        font-size: 1.1rem;
    }
    
    .visualization-grid {
        grid-template-columns: 1fr; /* ✅ 1 columna en móviles */
        gap: 15px;
    }

    .visualization-actions {
        flex-direction: column;
        align-items: flex-start;
    }

    .visualization-actions__buttons {
        width: 100%;
    }

    .btn-toggle-filter {
        width: 100%;
        justify-content: center;
    }
}
    
    .dipole-visualization-card {
        min-height: 400px;
    }
    
    .dipole-viewer {
        height: 280px;
    }
    
    .statistics-grid {
        grid-template-columns: 1fr;
        gap: 15px;
    }
    
    .stats-grid {
        grid-template-columns: 1fr;
        gap: 12px;
    }
    
    .stats-item {
        padding: 14px;
        font-size: 0.9rem;
    }
    
    .dipole-stats {
        grid-template-columns: 1fr;
        gap: 8px;
    }
    
    .sequence-container {
        max-width: 100%;
    }
    
    .sequence-text {
        font-size: 0.75rem;
    }
    
    .peptide-table {
        font-size: 0.85rem;
    }
    
    .peptide-table th,
    .peptide-table td {
        padding: 8px 6px;
    }
}

@media (max-width: 480px) {
    .family-container {
        padding: 8px;
    }
    
    .card-body {
        padding: 12px;
    }
    
    .visualization-grid {
        grid-template-columns: 1fr;
        gap: 12px;
    }
    
    .dipole-visualization-card {
        min-height: 350px;
    }
    
    .dipole-viewer {
        height: 220px;
    }
    
    .statistics-grid {
        grid-template-columns: 1fr;
        gap: 12px;
    }
    
    .stats-grid {
        grid-template-columns: 1fr;
        gap: 10px;
    }
    
    .stats-item {
        padding: 12px;
    }
    
    .page-title {
        font-size: 1.2rem;
    }
    
    /* ✅ Actualizado para nueva estructura */
    .selection-section {
        margin-bottom: 15px;
    }
    
    .action-section {
        min-height: 65px;
        margin: 15px 0;
        padding: 12px;
        border-radius: 8px;
    }
    
    .btn-lg {
        padding: 12px 20px;
        font-size: 0.95em;
        flex-wrap: wrap;
    }
    
    .btn {
        padding: 8px 12px;
        font-size: 0.85rem;
    }
    
    .dipole-card-header {
        padding: 10px 12px;
    }
    
    .dipole-card-title {
        font-size: 0.9rem;
    }
    
    .dipole-card-subtitle {
        font-size: 0.8rem;
    }
    
    .vector-code {
        font-size: 0.7rem;
        padding: 4px 6px;
    }
}

/* ===== MEJORAS PARA PANTALLAS ULTRAWIDE ===== */
@media (min-width: 1600px) {
    .family-container {
        max-width: 95%; /* ✅ Usar casi toda la pantalla en monitores grandes */
        padding: 25px;
    }
    
    .visualization-grid {
        gap: 25px;
    }
    
    .dipole-viewer {
        height: 420px;
    }
    
    .dipole-stats {
        grid-template-columns: repeat(4, 1fr); /* ✅ 4 columnas en pantallas grandes */
    }
}

@media (min-width: 1920px) {
    .family-container {
        max-width: 98%; /* ✅ Usar casi toda la pantalla en 4K */
        padding: 30px;
    }
    
    .visualization-grid {
        gap: 30px;
    }
    
    .dipole-viewer {
        height: 450px;
    }
}