/* ============================================
   PÁGINA FILTRO DE TOXINAS
   Vista de búsqueda y filtrado con resultados paginados
   ============================================ */

/* === LAYOUT === */
.filter-page {
    min-height: 100vh;
    background: #F7F8FA;
    padding-bottom: var(--space-16);
}

.filter-container {
    max-width: 1800px;
    margin: 0 auto;
    padding: var(--space-6);
}

/* === SECCIÓN DE VISUALIZACIÓN === */
.visualization-section {
    margin-bottom: var(--space-6);
}

.visualization-card {
    background: white;
    border-radius: 0.75rem;
    padding: 0;
    margin-bottom: var(--space-6);
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
    border: 1px solid rgba(0, 0, 0, 0.05);
    overflow: hidden;
    animation: slideDown var(--transition-slow) ease-out;
}

.visualization-card .card-header {
    background: #3B82F6;
    color: white;
    padding: var(--space-5);
    border-bottom: none;
}

.visualization-card .card-body {
    padding: var(--space-6);
}

.visualization-card .section-title {
    font-size: var(--text-2xl);
    font-weight: 700;
    display: flex;
    align-items: center;
    gap: var(--space-2);
}

.reference-section-title {
    display: flex;
    align-items: center;
    gap: var(--space-3);
    flex-wrap: wrap;
}

.reference-selector-dropdown {
    min-width: 220px;
    padding: 6px 12px;
    border-radius: var(--radius-md);
    border: 1px solid rgba(255, 255, 255, 0.65);
    background: rgba(255, 255, 255, 0.15);
    color: #fff;
    font-weight: 600;
    font-size: var(--text-sm);
    outline: none;
    transition: background var(--transition-base), border var(--transition-base), color var(--transition-base);
    backdrop-filter: blur(4px);
}

.reference-selector-dropdown option {
    color: var(--gray-900);
}

.reference-selector-dropdown:focus {
    border-color: rgba(255, 255, 255, 0.95);
    background: rgba(255, 255, 255, 0.3);
}

@media (max-width: 768px) {
    .reference-section-title {
        flex-direction: column;
        align-items: flex-start;
        gap: var(--space-2);
    }

    .reference-selector-dropdown {
        width: 100%;
    }
}

.visualization-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(320px, 1fr));
    gap: var(--space-5);
}

/* === FILTROS === */
.filters-section {
    background: white;
    border-radius: 0.75rem;
    padding: var(--space-6);
    margin-bottom: var(--space-6);
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
    animation: slideUp var(--transition-slow) ease-out;
    animation-delay: 100ms;
    border: 1px solid rgba(0, 0, 0, 0.05);
}

.filters-header {
    display: flex;
    align-items: center;
    gap: var(--space-3);
    margin-bottom: var(--space-5);
    padding-bottom: var(--space-4);
    border-bottom: 2px solid var(--gray-100);
}

.filters-icon {
    width: 48px;
    height: 48px;
    background: #3B82F6;
    border-radius: 0.5rem;
    display: flex;
    align-items: center;
    justify-content: center;
    color: white;
    font-size: var(--text-xl);
    box-shadow: 0 2px 8px rgba(59, 130, 246, 0.3);
}

.filters-title {
    font-size: var(--text-2xl);
    font-weight: 700;
    color: #0F172A;
    margin: 0;
}

.filters-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
    gap: var(--space-4);
    margin-bottom: var(--space-5);
}

.filter-input-group {
    display: flex;
    flex-direction: column;
    gap: var(--space-2);
}

.filter-label {
    font-weight: 600;
    color: #0F172A;
    font-size: var(--text-sm);
    display: flex;
    align-items: center;
    gap: var(--space-2);
}

.filter-label-icon {
    color: #3B82F6;
}

.filter-input {
    padding: var(--space-3);
    border: 1px solid #E2E8F0;
    border-radius: 0.5rem;
    font-size: var(--text-base);
    transition: all 0.2s ease;
}

.filter-input:focus {
    outline: none;
    border-color: #3B82F6;
    box-shadow: 0 0 0 3px rgba(59, 130, 246, 0.1);
}

/* Checkbox personalizado con animaciones */
.checkbox-wrapper {
    display: flex;
    align-items: center;
    gap: var(--space-3);
    cursor: pointer;
    user-select: none;
    padding: var(--space-3);
    border-radius: var(--radius-lg);
    transition: all var(--transition-base);
}

.checkbox-wrapper:hover {
    background: var(--gray-50);
}

.custom-checkbox {
    position: relative;
    width: 24px;
    height: 24px;
    min-width: 24px;
    border: 2px solid #CBD5E1;
    border-radius: 0.25rem;
    transition: all 0.2s ease;
}

.custom-checkbox:hover {
    border-color: #3B82F6;
    transform: scale(1.05);
}

.custom-checkbox.checked {
    background: #3B82F6;
    border-color: #3B82F6;
    animation: checkPop var(--transition-fast) ease-out;
}

.custom-checkbox.checked::after {
    content: '✓';
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    color: white;
    font-weight: 700;
    font-size: var(--text-sm);
    animation: fadeIn var(--transition-fast) ease-in;
}

@keyframes checkPop {
    0% { transform: scale(1); }
    50% { transform: scale(1.15); }
    100% { transform: scale(1); }
}

.checkbox-label {
    font-weight: 600;
    color: #0F172A;
    display: flex;
    align-items: center;
    gap: var(--space-2);
    font-size: var(--text-base);
}

/* Acciones de filtrado */
.filter-actions {
    display: flex;
    gap: var(--space-3);
    justify-content: flex-end;
    align-items: center;
}

.search-btn {
    padding: var(--space-4) var(--space-8);
    font-size: var(--text-lg);
    position: relative;
    overflow: hidden;
}

.btn-export {
    display: inline-flex;
    align-items: center;
    gap: var(--space-2);
    transition: all var(--transition-base);
}

.btn-export:disabled {
    opacity: 0.5;
    cursor: not-allowed;
}

.btn-export:not(:disabled):hover {
    transform: translateY(-2px);
    box-shadow: 0 6px 20px rgba(76, 175, 80, 0.4);
}

/* Estado del filtro */
.filter-status {
    padding: var(--space-4);
    background: #F7F8FA;
    border-radius: 0.5rem;
    border-left: 3px solid #3B82F6;
    margin-top: var(--space-5);
    display: flex;
    align-items: center;
    gap: var(--space-3);
    animation: fadeIn var(--transition-base) ease-in;
}

.status-icon {
    font-size: var(--text-xl);
    color: #3B82F6;
    animation: pulse 2s ease-in-out infinite;
}

@keyframes pulse {
    0%, 100% { opacity: 1; }
    50% { opacity: 0.5; }
}

.status-text {
    color: #475569;
    font-weight: 600;
}

/* === RESULTADOS FILTRADOS === */
.results-header {
    display: flex;
    align-items: center;
    justify-content: space-between;
    flex-wrap: wrap;
    gap: var(--space-4);
    margin-bottom: var(--space-6);
}

.results-title-wrapper {
    display: flex;
    align-items: center;
    gap: var(--space-3);
}

.results-icon {
    width: 56px;
    height: 56px;
    background: #3B82F6;
    border-radius: 0.5rem;
    display: flex;
    align-items: center;
    justify-content: center;
    color: white;
    font-size: var(--text-2xl);
    box-shadow: 0 2px 8px rgba(59, 130, 246, 0.3);
}

.results-title {
    font-size: var(--text-2xl);
    color: #0F172A;
    margin: 0;
}

.results-count {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    min-width: 40px;
    height: 40px;
    padding: 0 var(--space-3);
    background: #3B82F6;
    color: white;
    border-radius: var(--radius-full);
    font-weight: 800;
    font-size: var(--text-xl);
    box-shadow: 0 2px 8px rgba(59, 130, 246, 0.3);
}

/* Paginación */
.pagination-controls {
    display: flex;
    align-items: center;
    gap: var(--space-3);
}

.pagination-btn {
    padding: var(--space-3) var(--space-5);
    background: white;
    color: #1E40AF;
    border: 1px solid #3B82F6;
    border-radius: 0.5rem;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.2s ease;
}

.pagination-btn:hover:not(:disabled) {
    background: #3B82F6;
    color: white;
    transform: translateY(-1px);
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.3);
}

.pagination-btn:focus-visible {
    outline: 3px solid #93C5FD;
    outline-offset: 2px;
}

.pagination-btn:disabled {
    opacity: 0.4;
    cursor: not-allowed;
}

.page-indicator {
    padding: var(--space-2) var(--space-4);
    background: #F1F5F9;
    border-radius: 0.5rem;
    font-weight: 700;
    color: #475569;
}

/* Toggle buttons (Mostrar/Ocultar) share primary style and have an active state */
.btn-primary[aria-pressed="true"],
.btn-toggle.active {
    background: #1E40AF;
    color: #fff;
}

.btn-primary[aria-pressed="true"]:hover,
.btn-toggle.active:hover {
    background: #1E3A8A;
}

/* Grid de resultados filtrados */
.filtered-grid {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(350px, 1fr));
    gap: var(--space-5);
    margin-bottom: var(--space-6);
}

.filtered-dipole-card {
    background: white;
    border-radius: 0.75rem;
    overflow: hidden;
    border: 1px solid rgba(0, 0, 0, 0.05);
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
    transition: all 0.2s ease;
}

.filtered-dipole-card:hover {
    border-color: #3B82F6;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.15);
    transform: translateY(-2px);
}

.filtered-card-header {
    background: #3B82F6;
    color: white;
    padding: var(--space-3);
    text-align: center;
    font-weight: 700;
    font-size: var(--text-base);
}

.filtered-viewer {
    width: 100%;
    height: 320px;
    background: var(--gray-50);
    border-bottom: 2px solid var(--gray-200);
}

.filtered-info {
    padding: var(--space-4);
}

.filtered-properties {
    display: flex;
    flex-direction: column;
    gap: var(--space-2);
}

.filtered-property-row {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: var(--space-2);
    background: var(--gray-50);
    border-radius: var(--radius-sm);
}

.filtered-property-label {
    font-size: var(--text-sm);
    color: var(--gray-600);
    font-weight: 600;
}

.filtered-property-value {
    font-size: var(--text-sm);
    color: #1E40AF;
    font-weight: 700;
    font-family: var(--font-mono);
}

/* === TABLA DE RESULTADOS - DISEÑO MODERNO === */
.results-table-section {
    background: white;
    border-radius: 0.75rem;
    padding: var(--space-6);
    margin-bottom: var(--space-6);
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
    border: 1px solid rgba(0, 0, 0, 0.05);
}

.results-table-header {
    display: grid;
    grid-template-columns: auto 1fr auto;
    align-items: center;
    gap: var(--space-4);
    margin-bottom: var(--space-6);
    padding-bottom: var(--space-4);
    border-bottom: 2px solid var(--gray-100);
}

/* === GLOSARIO DE RESIDUOS (Diseño completo con toda la información) === */
.residue-glossary-full {
    background: #3B82F6;
    border-radius: var(--radius-lg);
    margin: 0 0 var(--space-6) 0;
    box-shadow: 0 4px 6px rgba(0, 0, 0, 0.1);
    animation: slideDown 0.3s ease-out;
    overflow: hidden;
}

.glossary-header-full {
    display: flex;
    justify-content: space-between;
    align-items: center;
    padding: var(--space-4) var(--space-5);
    background: #2563EB;
    border-bottom: 2px solid rgba(255, 255, 255, 0.2);
}

.glossary-title-row {
    display: flex;
    align-items: center;
    gap: var(--space-3);
}

.glossary-title-row i {
    color: white;
    font-size: 1.25rem;
}

.glossary-title-row h3 {
    margin: 0;
    color: white;
    font-size: var(--text-lg);
    font-weight: 700;
    letter-spacing: 0.3px;
}

.glossary-toggle-btn {
    background: rgba(255, 255, 255, 0.2);
    border: 1px solid rgba(255, 255, 255, 0.3);
    color: white;
    padding: var(--space-2) var(--space-3);
    border-radius: var(--radius-md);
    cursor: pointer;
    transition: all var(--transition-base);
    font-size: 0.875rem;
    display: flex;
    align-items: center;
    gap: var(--space-2);
}

.glossary-toggle-btn:hover {
    background: rgba(255, 255, 255, 0.3);
    transform: translateY(-1px);
}

.glossary-toggle-btn i {
    transition: transform 0.3s ease;
}

.glossary-toggle-btn[aria-expanded="false"] i {
    transform: rotate(180deg);
}

.glossary-content {
    padding: var(--space-5);
    background: #3B82F6;
    max-height: 1000px;
    overflow: hidden;
    transition: max-height 0.4s ease-out, padding 0.4s ease-out;
}

.glossary-content.collapsed {
    max-height: 0;
    padding: 0 var(--space-5);
}

.glossary-grid-full {
    display: grid;
    grid-template-columns: repeat(auto-fill, minmax(320px, 1fr));
    gap: var(--space-4);
}

.glossary-card {
    background: white;
    border-radius: var(--radius-lg);
    padding: var(--space-4);
    box-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
    transition: all var(--transition-base);
    border: 2px solid transparent;
    display: flex;
    align-items: center;
    gap: var(--space-3);
}

.glossary-card:hover {
    transform: translateY(-3px);
    box-shadow: 0 6px 16px rgba(0, 0, 0, 0.15);
    border-color: rgba(255, 255, 255, 0.5);
}

.residue-badge-full {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    min-width: 48px;
    height: 48px;
    padding: 0 var(--space-2);
    font-weight: 800;
    font-size: 1.125rem;
    border-radius: var(--radius-lg);
    font-family: 'Courier New', monospace;
    box-shadow: 0 2px 6px rgba(0, 0, 0, 0.2);
    flex-shrink: 0;
}

.residue-text {
    font-size: var(--text-sm);
    line-height: 1.6;
    color: var(--gray-700);
    margin: 0;
}

.residue-text strong {
    color: var(--gray-900);
    font-weight: 700;
}

@media (max-width: 1024px) {
    .glossary-grid-full {
        grid-template-columns: repeat(auto-fill, minmax(280px, 1fr));
    }
}

@media (max-width: 768px) {
    .glossary-grid-full {
        grid-template-columns: 1fr;
    }
    
    .glossary-title-row h3 {
        font-size: var(--text-base);
    }
    
    .residue-glossary-full {
        margin-bottom: var(--space-4);
    }
}

.results-table-controls {
    display: flex;
    align-items: center;
    gap: var(--space-3);
    flex-wrap: wrap;
}

/* Búsqueda mejorada */
.search-input-wrapper {
    position: relative;
    display: flex;
    align-items: center;
    gap: var(--space-2);
}

.search-input-wrapper input[type="search"] {
    padding: var(--space-3) var(--space-4) var(--space-3) var(--space-10);
    border: 2px solid var(--gray-200);
    border-radius: var(--radius-lg);
    font-size: var(--text-sm);
    min-width: 280px;
    transition: all var(--transition-base);
    font-family: var(--font-primary);
    color: var(--gray-900);
}

.search-input-wrapper input[type="search"]::placeholder {
    color: var(--gray-400);
}

.search-input-wrapper input[type="search"]:focus {
    outline: none;
    border-color: #3B82F6;
    box-shadow: 0 0 0 3px rgba(59, 130, 246, 0.1);
}

.search-icon {
    position: absolute;
    left: var(--space-3);
    color: var(--gray-400);
    pointer-events: none;
}

.btn-clear-search {
    padding: var(--space-2) var(--space-3);
    background: var(--gray-100);
    color: var(--gray-700);
    border: 1px solid var(--gray-200);
    border-radius: var(--radius-md);
    font-size: var(--text-sm);
    font-weight: 600;
    cursor: pointer;
    transition: all var(--transition-base);
}

.btn-clear-search:hover {
    background: var(--gray-200);
    border-color: var(--gray-300);
}

.toggle-table-btn {
    display: inline-flex;
    align-items: center;
    gap: var(--space-2);
    padding: var(--space-3) var(--space-5);
    background: white;
    color: #1E40AF;
    border: 1px solid #3B82F6;
    border-radius: 0.5rem;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.2s ease;
}

.toggle-table-btn span {
    color: #1E40AF;
}

.toggle-table-btn i {
    color: #1E40AF;
}

.toggle-table-btn:hover {
    background: #EFF6FF;
    border-color: #3B82F6;
    transform: translateY(-1px);
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.15);
}

.toggle-table-btn:focus-visible {
    outline: 3px solid #3B82F6;
    outline-offset: 2px;
}

/* Wrapper con scroll horizontal suave */
.results-table-wrapper {
    overflow-x: auto;
    overflow-y: visible;
    border-radius: var(--radius-lg);
    border: 1px solid var(--gray-200);
    background: white;
}

.results-table-wrapper::-webkit-scrollbar {
    height: 10px;
}

.results-table-wrapper::-webkit-scrollbar-track {
    background: var(--gray-100);
    border-radius: var(--radius-sm);
}

.results-table-wrapper::-webkit-scrollbar-thumb {
    background: #3B82F6;
    border-radius: var(--radius-sm);
}

.results-table-wrapper::-webkit-scrollbar-thumb:hover {
    background: #1E40AF;
}

.results-table {
    width: max-content;
    min-width: 100%;
    border-collapse: separate;
    border-spacing: 0;
    table-layout: auto;
}

.results-table thead {
    position: sticky;
    top: 0;
    z-index: 10;
}

.results-table th {
    padding: var(--space-4) var(--space-3);
    text-align: left;
    font-weight: 700;
    font-size: var(--text-xs);
    text-transform: uppercase;
    letter-spacing: 0.8px;
    white-space: nowrap;
    color: #0F172A;
    border-bottom: 2px solid #1E40AF;
    min-width: fit-content;
    background-color: #DBEAFE;
}

.results-table th:first-child {
    padding-left: var(--space-4);
    border-radius: var(--radius-lg) 0 0 0;
}

.results-table th:last-child {
    padding-right: var(--space-4);
    border-radius: 0 var(--radius-lg) 0 0;
}

/* Icono de ayuda en headers */
.header-help-icon {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    width: 18px;
    height: 18px;
    margin-left: 6px;
    background: rgba(11, 183, 240, 0.25);
    border-radius: 50%;
    font-size: 11px;
    font-weight: 700;
    cursor: help;
    transition: all var(--transition-fast);
    vertical-align: middle;
    color: white;
    border: 1px solid rgba(255, 255, 255, 0.3);
}

.header-help-icon:hover {
    background: rgba(255, 255, 255, 0.4);
    border-color: rgba(255, 255, 255, 0.5);
    transform: scale(1.2);
}

.results-table td {
    padding: var(--space-3);
    border-bottom: 1px solid var(--gray-100);
    font-size: var(--text-sm);
    color: var(--gray-900);
    vertical-align: middle;
    font-weight: 500;
    white-space: nowrap;
}

.results-table td:first-child {
    padding-left: var(--space-4);
    font-weight: 700;
    color: var(--primary-700);
}

.results-table td:last-child {
    padding-right: var(--space-4);
    max-width: 500px;
    min-width: 300px;
    position: relative;
}

/* Contenedor de secuencia con scroll horizontal */
.sequence-container {
    max-width: 100%;
    overflow-x: auto;
    overflow-y: hidden;
    padding: var(--space-1) 0;
}

.sequence-container::-webkit-scrollbar {
    height: 6px;
}

.sequence-container::-webkit-scrollbar-track {
    background: var(--gray-100);
    border-radius: 3px;
}

.sequence-container::-webkit-scrollbar-thumb {
    background: #60A5FA;
    border-radius: 3px;
}

.sequence-container::-webkit-scrollbar-thumb:hover {
    background: #3B82F6;
}

.results-table th:last-child {
    max-width: 500px;
    min-width: 300px;
}

.results-table tbody tr {
    transition: all var(--transition-fast);
    background: #EFF6FF;
}

.results-table tbody tr:nth-child(even) {
    background: white;
}

.results-table tbody tr:hover {
    background: linear-gradient(90deg, #DBEAFE 0%, #E0F2FE 100%);
    transform: scale(1.001);
    box-shadow: 0 2px 8px rgba(59, 130, 246, 0.12);
}

.results-table tbody tr:last-child td {
    border-bottom: none;
}

.results-table tbody tr:last-child td:first-child {
    border-radius: 0 0 0 var(--radius-lg);
}

.results-table tbody tr:last-child td:last-child {
    border-radius: 0 0 var(--radius-lg) 0;
}

/* Células especiales con badges modernos */
.table-cell-mono {
    font-family: var(--font-mono);
    color: #1F2937;
    font-weight: 600;
    font-size: 13px;
    background: linear-gradient(135deg, #F3F4F6 0%, #E5E7EB 100%);
    padding: var(--space-2) var(--space-3);
    border-radius: var(--radius-md);
    display: inline-block;
    line-height: 1.6;
    white-space: nowrap;
    border: 1px solid #D1D5DB;
    box-shadow: inset 0 1px 2px rgba(0, 0, 0, 0.05);
}

.table-cell-badge {
    display: inline-flex;
    align-items: center;
    justify-content: center;
    padding: var(--space-1) var(--space-3);
    background: #DBEAFE;
    color: #1E40AF;
    border-radius: var(--radius-full);
    font-weight: 700;
    font-size: var(--text-xs);
    border: 1px solid #93C5FD;
    box-shadow: none;
}

.text-muted {
    color: var(--gray-500);
    font-style: italic;
    font-weight: 400;
}

/* Estado vacío amigable */
.empty-state {
    text-align: center;
    padding: var(--space-12) var(--space-6);
    color: var(--gray-500);
}

.empty-state-icon {
    font-size: 3rem;
    color: var(--gray-300);
    margin-bottom: var(--space-4);
}

.empty-state-title {
    font-size: var(--text-xl);
    font-weight: 700;
    color: var(--gray-700);
    margin-bottom: var(--space-2);
}

.empty-state-description {
    font-size: var(--text-base);
    color: var(--gray-500);
    max-width: 400px;
    margin: 0 auto var(--space-6);
}

.empty-state-action {
    display: inline-flex;
    align-items: center;
    gap: var(--space-2);
    padding: var(--space-3) var(--space-6);
    background: #3B82F6;
    color: white;
    border: none;
    border-radius: 0.5rem;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.2s ease;
}

.empty-state-action:hover {
    background: #1E40AF;
    transform: translateY(-1px);
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.3);
}


/* === RESPONSIVE === */
@media (max-width: 1024px) {
    .filtered-grid {
        grid-template-columns: repeat(auto-fill, minmax(300px, 1fr));
    }
    
    .results-table-header {
        grid-template-columns: 1fr;
        gap: var(--space-3);
    }
    
    .results-table-controls {
        order: 2;
    }
    
    .toggle-table-btn {
        order: 3;
        width: 100%;
        justify-content: center;
    }
}

@media (max-width: 768px) {
    .filters-grid {
        grid-template-columns: 1fr;
    }
    
    .filtered-grid {
        grid-template-columns: 1fr;
    }
    
    .filter-actions {
        flex-direction: column;
    }
    
    .results-header {
        flex-direction: column;
        align-items: flex-start;
    }
    
    .pagination-controls {
        width: 100%;
        justify-content: space-between;
    }
    
    .search-input-wrapper input[type="search"] {
        min-width: 200px;
    }
    
    .results-table th,
    .results-table td {
        padding: var(--space-2);
        font-size: var(--text-xs);
    }
    
    .pagination-btn span {
        display: none;
    }
    
    .pagination-btn {
        padding: var(--space-2) var(--space-3);
    }
}

@media (max-width: 480px) {
    .results-table-section {
        padding: var(--space-4);
    }
    
    .search-input-wrapper {
        flex-direction: column;
        width: 100%;
    }
    
    .search-input-wrapper input[type="search"] {
        width: 100%;
        min-width: unset;
    }
    
    .filter-mode-tabs {
        width: 100%;
    }
    
    .filter-mode-tabs .tab-btn {
        flex: 1;
        min-width: unset;
        font-size: 0.75rem;
        padding: 6px 8px;
    }
}

/* === INLINE STYLES MOVED FROM HTML === */
/* Reset básico */
* { margin: 0; padding: 0; box-sizing: border-box; }
body { font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', Roboto, sans-serif; line-height: 1.6; color: #1a202c; background: #f8fafc; }
.container { max-width: 1400px; margin: 0 auto; padding: 0 1rem; }
:root { --row-h: 44px; --thead-h: 48px; --page-size: 10; --radius: 8px; }

/* Reserva de espacio para estabilidad y pintura temprana */
#reference-viewer { min-height: 320px; position: relative; background: #f9fafb; border-radius: 8px; }
#filtered-dipoles-card .card-body { min-height: 240px; }
.filter-container { min-height: 96px; padding: 8px 12px; }
#status-line { min-height: 22px; display:flex; align-items:center; }

/* Resultados: reservar altura estable para evitar CLS */
#results-card.results-table-section { position: relative; border-radius: var(--radius); contain: layout paint; content-visibility: auto; }
.results-table-header { min-height: 88px; }
.results-table-wrapper { min-height: calc(var(--thead-h) + var(--row-h) * var(--page-size)); }
.results-table { table-layout: fixed; width: 100%; }
.results-table thead th { height: var(--thead-h); }
.results-table tbody tr { height: var(--row-h); }
.pagination-controls { min-height: 44px; display:flex; align-items:center; }
.is-hidden-keep-space { visibility: hidden; }

/* Skeleton para filas */
.skeleton-row td { position: relative; overflow: hidden; background: var(--gray-50); }
.skeleton-row td::after { content: ''; position: absolute; inset: 8px 16px; background: linear-gradient(90deg,var(--gray-100) 25%, var(--gray-200) 37%, var(--gray-100) 63%); background-size: 400% 100%; animation: skeleton 1.2s ease-in-out infinite; border-radius: 4px; }
@keyframes skeleton { 0%{background-position:100% 50%} 100%{background-position:0 50%} }

/* Tabs de filtro en la tabla de resultados */
.filter-mode-tabs {
    display: flex;
    flex-wrap: wrap;
    gap: .5rem;
    align-items: center;
}
.filter-mode-tabs .tab-btn {
    display: inline-flex;
    align-items: center;
    padding: 8px 12px;
    border-radius: 999px;
    border: 1.5px solid var(--gray-300);
    background: #fff;
    color: var(--gray-700);
    font-weight: 600;
    font-size: 0.85rem;
    line-height: 1;
    cursor: pointer;
    transition: background .2s ease, border-color .2s ease, color .2s ease, box-shadow .2s ease;
}
.filter-mode-tabs .tab-btn:hover { background: var(--gray-50); border-color: var(--gray-400); }
.filter-mode-tabs .tab-btn.active {
    background: #3B82F6;
    color: #ffffff;
    border-color: #3B82F6;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.3);
}
@media (max-width: 640px) {
    .filter-mode-tabs { gap: .4rem; }
    .filter-mode-tabs .tab-btn { flex: 1 1 auto; justify-content: center; min-width: 120px; }
}

/* Estilos para los botones de modo de visualización */
.view-mode-controls {
    display: flex;
    gap: 1rem;
    justify-content: center;
    padding: 1.5rem;
    background: #F7F8FA;
    border-radius: 8px;
    margin: 1rem 1.5rem;
}

.btn-view-mode {
    background: white;
    color: var(--gray-600);
    border: 2px solid var(--gray-200);
    padding: 12px 24px;
    border-radius: 8px;
    font-size: 14px;
    font-weight: 600;
    cursor: pointer;
    transition: all 0.3s ease;
    box-shadow: 0 2px 4px rgba(0, 0, 0, 0.05);
    display: flex;
    align-items: center;
    gap: 8px;
}

.btn-view-mode:hover {
    transform: translateY(-2px);
    box-shadow: 0 4px 12px rgba(0, 0, 0, 0.1);
    border-color: var(--gray-300);
}

.btn-view-mode:active {
    transform: translateY(0);
}

.btn-view-mode.active {
    background: #3B82F6;
    color: white;
    border-color: #3B82F6;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.3);
}

.btn-view-mode.active:hover {
    background: #1E40AF;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.4);
}

.btn-view-mode i {
    font-size: 16px;
}

/* Animación al cambiar de modo */
@keyframes modeChange {
    0% { opacity: 0; transform: scale(0.95); }
    100% { opacity: 1; transform: scale(1); }
}

.visualization-grid.mode-changing {
    animation: modeChange 0.3s ease;
}

/* Botones IC50 (Todos / Con / Sin) */
.ic50-filter-btn {
    display: inline-flex;
    align-items: center;
    gap: 8px;
    padding: 10px 16px;
    border: 2px solid var(--gray-200);
    border-radius: 999px;
    background: linear-gradient(180deg, #ffffff 0%, var(--gray-50) 100%);
    color: var(--gray-700);
    font-weight: 600;
    font-size: 0.95rem;
    cursor: pointer;
    transition: transform .15s ease, box-shadow .2s ease, border-color .2s ease, background .2s ease;
    box-shadow: 0 2px 8px rgba(15, 23, 42, .06);
}
.ic50-filter-btn:hover {
    transform: translateY(-1px);
    box-shadow: 0 6px 16px rgba(15, 23, 42, .12);
    border-color: var(--gray-300);
}
.ic50-filter-btn .icon { font-size: 1rem; opacity: .85; }
.ic50-filter-btn.active {
    background: #3B82F6;
    color: #fff;
    border-color: #3B82F6;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.3);
}
.ic50-filter-btn:disabled { opacity: .7; cursor: not-allowed; transform: none; box-shadow: none; }

/* Overlay de carga sobre el grid de dipolos */
#filtered-dipoles-card .card-body { position: relative; }
.ic50-loading-overlay {
    position: absolute;
    inset: 0;
    background: rgba(255,255,255,0.85);
    backdrop-filter: blur(2px);
    display: none;
    align-items: center;
    justify-content: center;
    z-index: 5;
}
.ic50-loading-box {
    display: inline-flex;
    align-items: center;
    gap: 12px;
    padding: 12px 18px;
    border-radius: 10px;
    background: #ffffff;
    box-shadow: 0 8px 22px rgba(0,0,0,.12);
    color: var(--gray-700);
    font-weight: 600;
}
.ic50-spinner {
    width: 18px; height: 18px;
    border: 3px solid var(--gray-200);
    border-top-color: var(--primary-500);
    border-radius: 50%;
    animation: ic50spin .9s linear infinite;
}
@keyframes ic50spin { to { transform: rotate(360deg); } }

/* Overlay de carga para Gráficos */
#charts-card .card-body { position: relative; }
.charts-loading-overlay {
    position: absolute;
    inset: 0;
    background: rgba(255,255,255,0.85);
    backdrop-filter: blur(2px);
    display: none;
    align-items: center;
    justify-content: center;
    z-index: 5;
}
.charts-loading-box {
    display: inline-flex;
    align-items: center;
    gap: 12px;
    padding: 12px 18px;
    border-radius: 10px;
    background: #ffffff;
    box-shadow: 0 8px 22px rgba(0,0,0,.12);
    color: var(--gray-700);
    font-weight: 600;
}
.charts-spinner {
    width: 18px; height: 18px;
    border: 3px solid var(--gray-200);
    border-top-color: var(--primary-600);
    border-radius: 50%;
    animation: ic50spin .9s linear infinite;
}

/* === INTRO (encabezado mejorado con grid y badges) === */
.page-intro {
    background: #FFFFFF;
    border-radius: 0.75rem;
    padding: var(--space-8);
    margin-bottom: var(--space-6);
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
    border: 1px solid rgba(0, 0, 0, 0.05);
    position: relative;
    overflow: hidden;
}

.page-intro::before {
    content: '';
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 3px;
    background: #3B82F6;
}

.intro-header { 
    display: flex; 
    align-items: center; 
    gap: var(--space-4); 
    margin-bottom: var(--space-6); 
    padding-bottom: var(--space-4);
    border-bottom: 2px solid var(--gray-100);
}

.intro-icon {
    width: 64px; 
    height: 64px; 
    display: flex; 
    align-items: center; 
    justify-content: center;
    border-radius: 0.5rem;
    background: #3B82F6;
    color: #fff; 
    box-shadow: 0 2px 8px rgba(59, 130, 246, 0.3);
    font-size: var(--text-2xl);
}

.intro-title {
    margin: 0 0 8px 0;
    font-size: clamp(1.5rem, 1.25rem + 0.8vw, 2rem);
    font-weight: 700;
    color: #0F172A;
    line-height: 1.2;
}

.intro-lead { 
    margin: 0; 
    color: #475569; 
    font-size: var(--text-lg);
    font-weight: 400;
    max-width: 90ch; 
}

/* Grid de secciones explicativas */
.intro-grid {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--space-5);
    margin-bottom: var(--space-6);
}

.intro-section {
    background: #FFFFFF;
    border-radius: 0.75rem;
    padding: var(--space-5);
    border: 1px solid rgba(0, 0, 0, 0.05);
    transition: all 0.2s ease;
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
}

.intro-section:hover {
    border-color: #3B82F6;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.15);
    transform: translateY(-2px);
}

.intro-section--highlight {
    background: #FFFFFF;
    border-color: #3B82F6;
    border-width: 1px;
}

.intro-section-icon {
    width: 40px;
    height: 40px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: #3B82F6;
    color: white;
    border-radius: 0.5rem;
    font-size: var(--text-lg);
    margin-bottom: var(--space-3);
    box-shadow: 0 2px 8px rgba(59, 130, 246, 0.3);
}

.intro-section--highlight .intro-section-icon {
    background: #3B82F6;
}

.intro-section-title {
    margin: 0 0 var(--space-3) 0;
    font-size: var(--text-lg);
    font-weight: 600;
    color: #0F172A;
}

.intro-section-text {
    margin: 0;
    font-size: var(--text-sm);
    line-height: 1.6;
    color: #475569;
}

/* Badge del motivo CXCX */
.motif-badge {
    display: inline-flex;
    align-items: center;
    padding: 2px 8px;
    background: #3B82F6;
    color: white;
    border-radius: 0.375rem;
    font-family: var(--font-mono, ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace);
    font-size: 0.9em;
    font-weight: 600;
    box-shadow: 0 2px 6px rgba(59, 130, 246, 0.3);
    white-space: nowrap;
}

/* Referencia al paper */
.paper-reference {
    margin-top: var(--space-3);
    padding: var(--space-4);
    background: #F7F8FA;
    border-radius: 0.5rem;
    border-left: 3px solid #3B82F6;
    box-shadow: none;
}

.paper-title {
    display: block;
    font-size: var(--text-sm);
    font-style: italic;
    color: #0F172A;
    margin-bottom: var(--space-3);
    line-height: 1.5;
}

.paper-link {
    display: inline-flex;
    align-items: center;
    gap: var(--space-2);
    padding: var(--space-2) var(--space-4);
    background: #3B82F6;
    color: white;
    text-decoration: none;
    border-radius: 0.5rem;
    font-size: var(--text-sm);
    font-weight: 600;
    transition: all 0.2s ease;
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
}

.paper-link:hover {
    background: #1E40AF;
    transform: translateY(-1px);
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.3);
}

.paper-link:focus-visible {
    outline: 3px solid #93C5FD;
    outline-offset: 2px;
}

/* Controles de visualización mejorados */
.visualization-controls {
    display: grid;
    grid-template-columns: repeat(auto-fit, minmax(280px, 1fr));
    gap: var(--space-4);
    padding-top: var(--space-5);
    border-top: 1px solid rgba(0, 0, 0, 0.05);
}

.viz-toggle-card {
    display: flex;
    align-items: center;
    gap: var(--space-3);
    padding: var(--space-4);
    background: #FFFFFF;
    border: 1px solid rgba(0, 0, 0, 0.05);
    border-radius: 0.75rem;
    cursor: pointer;
    transition: all 0.2s ease;
    text-align: left;
    width: 100%;
    box-shadow: 0 1px 3px rgba(0, 0, 0, 0.1);
}

.viz-toggle-card:hover {
    border-color: #3B82F6;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.15);
    transform: translateY(-2px);
}

.viz-toggle-card[aria-pressed="true"] {
    background: #EFF6FF;
    border-color: #3B82F6;
    box-shadow: 0 4px 12px rgba(59, 130, 246, 0.2);
}

.viz-card-icon {
    width: 48px;
    height: 48px;
    min-width: 48px;
    display: flex;
    align-items: center;
    justify-content: center;
    background: #EFF6FF;
    color: #3B82F6;
    border-radius: 0.5rem;
    font-size: 1.25rem;
}

.viz-toggle-card[aria-pressed="true"] .viz-card-icon {
    background: #3B82F6;
    color: white;
}

.viz-card-content {
    flex: 1;
}

.viz-card-title {
    margin: 0 0 4px 0;
    font-size: 1rem;
    font-weight: 600;
    color: #0F172A;
}

.viz-card-desc {
    margin: 0;
    font-size: 0.875rem;
    color: #64748B;
}

.viz-card-status {
    display: flex;
    align-items: center;
    gap: var(--space-2);
}

.status-badge {
    padding: 4px 8px;
    border-radius: 12px;
    font-size: 0.75rem;
    font-weight: 600;
    text-transform: uppercase;
    letter-spacing: 0.5px;
}

.status-hidden {
    background: #F1F5F9;
    color: #64748B;
}

.status-visible {
    background: #DBEAFE;
    color: #1E40AF;
}

.viz-chevron {
    color: #94A3B8;
    transition: transform 0.2s ease;
    font-size: 0.875rem;
}

.viz-toggle-card[aria-pressed="true"] .viz-chevron {
    transform: rotate(180deg);
    color: #3B82F6;
}

/* Navegación rápida */
.quick-nav {
    margin-top: var(--space-4);
    text-align: center;
}

.quick-nav-link {
    display: inline-flex;
    align-items: center;
    gap: var(--space-2);
    padding: var(--space-2) var(--space-4);
    color: #64748B;
    text-decoration: none;
    font-size: 0.875rem;
    font-weight: 500;
    transition: color 0.2s ease;
}

.quick-nav-link:hover {
    color: #3B82F6;
}

/* Responsive para intro */
@media (max-width: 768px) {
    .intro-header { 
        flex-direction: column; 
        align-items: flex-start;
        text-align: left;
    }
    
    .intro-grid {
        grid-template-columns: 1fr;
    }
    
    .intro-actions {
        flex-direction: column;
        width: 100%;
    }
    
    .btn-intro-action {
        width: 100%;
    }
}

/* Utilidades de layout para headers de tarjetas */
.card-header-row { display: flex; align-items: center; justify-content: space-between; gap: 1rem; }
.header-actions { display: flex; gap: .5rem; align-items: center; }
.visualization-card .section-title { margin: 0; }

/* Ajustes de viewer y etiquetas */
.reference-sequence {
    margin-left: 8px;
    font-family: var(--font-mono, ui-monospace, SFMono-Regular, Menlo, Monaco, Consolas, "Liberation Mono", "Courier New", monospace);
    font-size: 0.95rem; color: #0F172A;
}
#filtered-dipoles-card #page-indicator { margin: 0 8px; }

/* === CHARTS === */
.chart-block { width: 100%; height: 420px; }
.chart-block--compact { height: 380px; margin-top: 16px; }
.chart-title { margin: 0 0 8px 0; font-size: 14px; color: #475569; font-weight: 600; }
.chart-canvas { width: 100%; height: 380px; }
.chart-canvas--compact { height: 340px; }